DSM 74( DSM74 )

Catalog No. M16464 CAS No. 898743-92-5

A potent, orally active PfDHODH inhibitor (IC50=0.3 uM) with antimalarial activity.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
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50MG	1782	Get Quote
100MG	2250	Get Quote
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Biological Information

Product Name

DSM 74
Note

Research use only, not for human use.
Brief Description

A potent, orally active PfDHODH inhibitor (IC50=0.3 uM) with antimalarial activity.
Description

A potent, orally active PfDHODH inhibitor (IC50=0.3 uM) with antimalarial activity; shows good plasma exposure in mice and is equally potent against PfDHODH and PbDHODH; suppresses growth of P. berghei in mice after oral administration.
In Vitro

——
In Vivo

——
Synonyms

DSM74
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

Chemical Information

CAS Number

898743-92-5
Formula Weight

293.253
Molecular Formula

C13H10F3N5
Purity

>98% (HPLC)
Solubility

——
SMILES

FC(C1=CC=C(NC2=CC(C)=NC3=NC=NN23)C=C1)(F)F
Chemical Name

5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Lukens AK, e tal. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):799-804. 2. Gujjar R, et al. J Med Chem. 2009 Apr 9;52(7):1864-72. 3. Lee JJ, et al. urr Microbiol. 2014 Sep;69(3):286-91.

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